| Index | Fredericktown | Missouri | National |
| Cost of living | 85 | 90 | 100 |
| Groceries | 97 | 96 | 100 |
| Health care | 96 | 97 | 100 |
| Housing | 55 | 77 | 100 |
| Transportation | 99 | 96 | 100 |
| Utilities | 98 | 95 | 100 |
| Lifestyle & Entertainment | 95 | 95 | 100 |
| Household Items | 99 | 97 | 100 |
| Education & Childcare | 96 | 95 | 100 |

| Cost of living index | |
| Groceries index | |
| Health care index | |
| Housing index | |
| Transportation index | |
| Utilities index | |
| Lifestyle index | |
| Household index | |
| Educare index |
| Median Income | Per Year | Per Month | Max Budget (28% DTI) | Max Budget (36% DTI) |
| Owners | $70,662 | $5,889 | $1,649 | $2,120 |
| Renters | $33,674 | $2,806 | $786 | $1,010 |
| State | General Sales Tax | With Max Surtax |
| Missouri | 4.225% | 10.85% |
| State | Income Tax (Low) | Income Tax (High) |
| Missouri | 2% | 4.95% |
| City | Population | Cost of Living Index | National Avg. |
| Doe Run, MO | 670 | 76 | 23.8% |
| Cobalt, MO | 217 | 77 | 23.0% |
| Marquand, MO | 198 | 82 | 18.1% |
| Mine La Motte, MO | 399 | 82 | 17.8% |
| Junction City, MO | 277 | 83 | 17.5% |
| Fredericktown, MO | 4,146 | 85 | 15.5% |
| City | Population | Cost of Living Index | National Avg. |
| Lakewood, IL | 4,146 | 136 | 36.0% |
| Rosewood Heights, IL | 4,146 | 88 | 11.6% |
| Paintsville, KY | 4,145 | 91 | 9.0% |
| McLoud, OK | 4,147 | 88 | 12.1% |
| San Joaquin, CA | 4,144 | 112 | 11.7% |
| Fredericktown, MO | 4,146 | 85 | 15.5% |