| Index | Tuscumbia | Alabama | National |
| Cost of living | 87 | 89 | 100 |
| Groceries | 95 | 96 | 100 |
| Health care | 97 | 95 | 100 |
| Housing | 67 | 74 | 100 |
| Transportation | 98 | 95 | 100 |
| Utilities | 96 | 97 | 100 |
| Lifestyle & Entertainment | 94 | 94 | 100 |
| Household Items | 95 | 96 | 100 |
| Education & Childcare | 91 | 93 | 100 |

| Cost of living index | |
| Groceries index | |
| Health care index | |
| Housing index | |
| Transportation index | |
| Utilities index | |
| Lifestyle index | |
| Household index | |
| Educare index |
| Median Income | Per Year | Per Month | Max Budget (28% DTI) | Max Budget (36% DTI) |
| Owners | $87,386 | $7,282 | $2,039 | $2,622 |
| Renters | $43,019 | $3,585 | $1,004 | $1,291 |
| State | General Sales Tax | With Max Surtax |
| Alabama | 4% | 13.5% |
| State | Income Tax (Low) | Income Tax (High) |
| Alabama | 2% | 5% |
| City | Population | Cost of Living Index | National Avg. |
| Leighton, AL | 806 | 79 | 20.6% |
| Cherokee, AL | 898 | 83 | 17.5% |
| Russellville, AL | 10,174 | 84 | 16.0% |
| Sheffield, AL | 9,116 | 85 | 14.8% |
| Underwood-Petersville, AL | 2,778 | 86 | 14.3% |
| Tuscumbia, AL | 8,741 | 87 | 13.2% |
| City | Population | Cost of Living Index | National Avg. |
| Perryville, MO | 8,741 | 91 | 8.6% |
| Dalhart, TX | 8,740 | 91 | 9.1% |
| Fallon, NV | 8,742 | 102 | 2.2% |
| Park Hills, MO | 8,743 | 83 | 17.0% |
| Malverne, NY | 8,738 | 152 | 51.5% |
| Tuscumbia, AL | 8,741 | 87 | 13.2% |