| Index | Puxico | Missouri | National |
| Income per capita | $31,235 | $39,715 | $44,883 |
| Median household income | $72,398 | $72,613 | $81,333 |
| Median income owner occupied | $76,374 | $90,986 | $106,172 |
| Median income renter occupied | $50,228 | $45,210 | $52,080 |
| Median earnings male | $57,344 | $52,324 | $54,343 |
| Median earnings female | $44,522 | $36,971 | $38,439 |
| Unemployment rate | 4.0% | 4.4% | 4.9% |
| Poverty level | 10.2% | 15.3% | 15.1% |

| Labour Type | Male | Female |
| Construction industry | 1.5% | 1.5% |
| Manufacturing sector | 28.2% | 28.2% |
| Financial & insurance services | 1.2% | 1.2% |
| Wholesale & retail services | 3.1% | 3.1% |
| Public administration | 8.9% | 8.9% |
| Transportation, warehousing & utilities | 6.6% | 6.6% |
| Education, health & social services | 10.8% | 10.8% |
| Other | 39.8% | 39.8% |
| City | Population | Household Income | National Avg. |
| Fisk, MO | 578 | $68,220 | 16.1% |
| Advance, MO | 1,468 | $59,338 | 27.0% |
| Dexter, MO | 8,103 | $58,527 | 28.0% |
| Bloomfield, MO | 2,482 | $57,692 | 29.1% |
| Poplar Bluff, MO | 17,570 | $53,468 | 34.3% |
| Puxico, MO | 1,177 | $72,398 | 11.0% |
| City | Population | Household Income | National Avg. |
| Rossville, IL | 1,177 | $67,304 | 17.2% |
| Richfield Springs, NY | 1,177 | $57,887 | 28.8% |
| Holgate, OH | 1,177 | $72,286 | 11.1% |
| Republic, WA | 1,177 | $47,752 | 41.3% |
| John d'Or Prairie 215, AB | 1,177 | n/a | |
| Puxico, MO | 1,177 | $72,398 | 11.0% |