| Index | Puxico | Missouri | National |
| Average Test Scores | 31% | 44% | 48% |
| Student/Teacher ratio | 26:1 | 14:1 | 16:1 |
| Total public schools | 3 | 1,899 | 79,221 |
| Total private schools | n/a | 531 | 24,874 |
| Total post-secondary schools | n/a | 213 | 7,963 |
| Index | Puxico | Missouri | National |
| Completed 8th grade | 77.0% | 86.0% | 84.3% |
| Completed high school | 73.5% | 84.2% | 83.0% |
| Completed some college | 43.7% | 57.7% | 59.4% |
| Completed associate degree | 24.7% | 35.2% | 38.5% |
| Completed bachelors | 19.0% | 27.6% | 30.3% |
| Completed masters | 7.9% | 10.4% | 11.5% |
| Completed professional degree | 1.2% | 2.8% | 3.3% |
| Completed doctorate | 0.8% | 1.2% | 1.3% |
There are a total of 3 public schools, n/a private schools and n/a post-secondary schools in Puxico. Using the proficiency score averages, the average test scores for Puxico, MO schools is 31%. The average student to teacher ratio is 26:1. In Puxico, MO, an average of 77.0% of students have completed 8th grade and an average of 73.5% have completed high school.
| City | Population | Avg. Test Scores | National Avg. |
| Poplar Bluff, MO | 17,570 | 56% | 16.3% |
| Bloomfield, MO | 2,482 | 55% | 13.9% |
| Advance, MO | 1,468 | 47% | 2.1% |
| Zalma, MO | 62 | 45% | 5.7% |
| Dexter, MO | 8,103 | 45% | 5.9% |
| Puxico, MO | 1,177 | 31% | 35.4% |
| City | Population | Avg. Test Scores | National Avg. |
| Holgate, OH | 1,177 | 77% | 60.4% |
| Republic, WA | 1,177 | 46% | 4.2% |
| Rossville, IL | 1,177 | 20% | 59.4% |
| Richfield Springs, NY | 1,177 | 47% | 2.1% |
| Atwater, MN | 1,176 | 50% | 3.1% |
| Puxico, MO | 1,177 | 31% | 35.4% |
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