Tupelo, MS has a population of 38,856 and is the 1,069th largest city in the United States. The population density is 604 per sq mi which is 879% higher than the Mississippi average and 566% higher than the national average. The median age in Tupelo is 36 which is approximately 3% lower than the Mississippi average of 37. In Tupelo, 53% of the population over 15 years of age are married, 95% speak English and 4% speak Spanish. 73% of Tupelo residents were born in Mississippi, 24% were born out of state, 1% were born outside of the United States and 2% were foreign born.