Pontotoc, MS has a population of 5,906 and is the 5,813th largest city in the United States. The population density is 528 per sq mi which is 757% higher than the Mississippi average and 483% higher than the national average. The median age in Pontotoc is 37 which is approximately 1% higher than the Mississippi average of 37. In Pontotoc, 43% of the population over 15 years of age are married, 93% speak English and 7% speak Spanish. 73% of Pontotoc residents were born in Mississippi, 22% were born out of state, 0% were born outside of the United States and 5% were foreign born.