Otis, CO has a population of 433 and is the 20,440th largest city in the United States. The population density is 1,048 per sq mi which is 2006% higher than the Colorado average and 1057% higher than the national average. The median age in Otis is 34 which is approximately 7% lower than the Colorado average of 36. In Otis, 60% of the population over 15 years of age are married, 94% speak English and 6% speak Spanish. 64% of Otis residents were born in Colorado, 34% were born out of state, 0% were born outside of the United States and 1% were foreign born.