| Index | Kirksville | Missouri | National |
| Average Test Scores | 44% | 44% | 48% |
| Student/Teacher ratio | 14:1 | 14:1 | 16:1 |
| Total public schools | 5 | 1,899 | 79,221 |
| Total private schools | 3 | 531 | 24,874 |
| Total post-secondary schools | 4 | 213 | 7,963 |
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| Index | Kirksville | Missouri | National |
| Completed 8th grade | 90.1% | 86.0% | 84.3% |
| Completed high school | 87.6% | 84.2% | 83.0% |
| Completed some college | 57.9% | 57.7% | 59.4% |
| Completed associate degree | 40.5% | 35.2% | 38.5% |
| Completed bachelors | 33.5% | 27.6% | 30.3% |
| Completed masters | 16.7% | 10.4% | 11.5% |
| Completed professional degree | 7.0% | 2.8% | 3.3% |
| Completed doctorate | 4.8% | 1.2% | 1.3% |
There are a total of 5 public schools, 3 private schools and 4 post-secondary schools in Kirksville. Using the proficiency score averages, the average test scores for Kirksville, MO schools is 44%. The average student to teacher ratio is 14:1. In Kirksville, MO, an average of 90.1% of students have completed 8th grade and an average of 87.6% have completed high school.
| City | Population | Avg. Test Scores | National Avg. |
| Brashear, MO | 143 | 50% | 4.2% |
| La Plata, MO | 1,192 | 47% | 2.1% |
| Queen City, MO | 702 | 43% | 9.9% |
| Novinger, MO | 333 | 40% | 17.2% |
| Kirksville, MO | 17,645 | 44% | 8.0% |
| City | Population | Avg. Test Scores | National Avg. |
| Santa Fe Springs, CA | 17,643 | 49% | 1.0% |
| Macomb, IL | 17,658 | 30% | 37.0% |
| Bay City, TX | 17,672 | 35% | 26.5% |
| Tallmadge, OH | 17,681 | 69% | 44.4% |
| Spanish Lake, MO | 17,682 | 17% | 63.7% |
| Kirksville, MO | 17,645 | 44% | 8.0% |
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