Kirksville, MO has a population of 17,592 and is the 2,461st largest city in the United States. The population density is 1,223 per sq mi which is 1316% higher than the Missouri average and 1250% higher than the national average. The median age in Kirksville is 24 which is approximately 39% lower than the Missouri average of 38. In Kirksville, 36% of the population over 15 years of age are married, 94% speak English and 1% speak Spanish. 62% of Kirksville residents were born in Missouri, 33% were born out of state, 1% were born outside of the United States and 4% were foreign born.