| Index | Kirksville | Missouri | National |
| Income per capita | $33,329 | $39,715 | $44,883 |
| Median household income | $53,184 | $72,613 | $81,333 |
| Median income owner occupied | $78,412 | $90,986 | $106,172 |
| Median income renter occupied | $31,341 | $45,210 | $52,080 |
| Median earnings male | $32,349 | $52,324 | $54,343 |
| Median earnings female | $19,240 | $36,971 | $38,439 |
| Unemployment rate | 4.5% | 4.4% | 4.9% |
| Poverty level | 28.8% | 15.3% | 15.1% |

| Labour Type | Male | Female |
| Construction industry | 6.2% | 6.2% |
| Manufacturing sector | 15.1% | 15.1% |
| Financial & insurance services | 1.2% | 1.2% |
| Wholesale & retail services | 11.8% | 11.8% |
| Public administration | 5.3% | 5.3% |
| Transportation, warehousing & utilities | 6.0% | 6.0% |
| Education, health & social services | 25.8% | 25.8% |
| Other | 27.4% | 27.4% |
| City | Population | Household Income | National Avg. |
| Millard, MO | 75 | $61,978 | 23.8% |
| Queen City, MO | 726 | $60,779 | 25.3% |
| Greentop, MO | 612 | $59,580 | 26.7% |
| La Plata, MO | 1,231 | $59,035 | 27.4% |
| Brashear, MO | 149 | $58,697 | 27.8% |
| Kirksville, MO | 18,120 | $53,184 | 34.6% |
| City | Population | Household Income | National Avg. |
| New Philadelphia, OH | 18,121 | $68,107 | 16.3% |
| Zachary, LA | 18,126 | $132,763 | 63.2% |
| Bon Air, VA | 18,126 | $131,213 | 61.3% |
| Bay City, TX | 18,090 | $68,307 | 16.0% |
| Tiffin, OH | 18,151 | $63,397 | 22.1% |
| Kirksville, MO | 18,120 | $53,184 | 34.6% |