| Index | Kirksville | Missouri | National |
| Income per capita | $22,418 | $27,044 | $29,829 |
| Median household income | $36,228 | $49,593 | $55,322 |
| Median income owner occupied | $53,426 | $62,242 | $70,586 |
| Median income renter occupied | $20,999 | $30,016 | $35,192 |
| Median earnings male | $21,690 | $34,901 | $36,919 |
| Median earnings female | $12,899 | $24,771 | $26,250 |
| Unemployment rate | 3.4% | 4.1% | 4.7% |
| Poverty level | 28.8% | 15.3% | 15.1% |


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| Labour Type | Male | Female |
| Construction industry | 6.2% | 6.2% |
| Manufacturing sector | 15.1% | 15.1% |
| Financial & insurance services | 1.2% | 1.2% |
| Wholesale & retail services | 11.8% | 11.8% |
| Public administration | 5.3% | 5.3% |
| Transportation, warehousing & utilities | 6.0% | 6.0% |
| Education, health & social services | 25.8% | 25.8% |
| Other | 27.4% | 27.4% |
| City | Population | Household Income | National Avg. |
| Queen City, MO | 702 | $41,591 | 24.8% |
| Millard, MO | 74 | $41,250 | 25.4% |
| Greentop, MO | 591 | $40,714 | 26.4% |
| La Plata, MO | 1,192 | $40,000 | 27.7% |
| Brashear, MO | 143 | $38,750 | 30.0% |
| Kirksville, MO | 17,645 | $36,228 | 34.5% |
| City | Population | Household Income | National Avg. |
| Santa Fe Springs, CA | 17,643 | $69,922 | 26.4% |
| Bryn Mawr-Skyway, WA | 17,643 | $76,190 | 37.7% |
| Bracebridge, ON | 17,648 | n/a | |
| Macomb, IL | 17,658 | $34,467 | 37.7% |
| Bay City, TX | 17,672 | $45,089 | 18.5% |
| Kirksville, MO | 17,645 | $36,228 | 34.5% |