| Index | Tuscumbia | Missouri | National |
| Cost of living | 84 | 90 | 100 |
| Groceries | 98 | 96 | 100 |
| Health care | 99 | 97 | 100 |
| Housing | 57 | 77 | 100 |
| Transportation | 95 | 96 | 100 |
| Utilities | 95 | 95 | 100 |
| Lifestyle & Entertainment | 92 | 95 | 100 |
| Household Items | 99 | 97 | 100 |
| Education & Childcare | 92 | 95 | 100 |

| Cost of living index | |
| Groceries index | |
| Health care index | |
| Housing index | |
| Transportation index | |
| Utilities index | |
| Lifestyle index | |
| Household index | |
| Educare index |
| Median Income | Per Year | Per Month | Max Budget (28% DTI) | Max Budget (36% DTI) |
| Owners | $111,341 | $9,278 | $2,598 | $3,341 |
| Renters | $0 | $0 | $0 | $0 |
| State | General Sales Tax | With Max Surtax |
| Missouri | 4.225% | 10.85% |
| State | Income Tax (Low) | Income Tax (High) |
| Missouri | 2% | 4.95% |
| City | Population | Cost of Living Index | National Avg. |
| Lakeside, MO | 0 | 96 | 4.1% |
| Olean, MO | 69 | 96 | 4.1% |
| Barnett, MO | 236 | 79 | 20.8% |
| Iberia, MO | 657 | 81 | 19.0% |
| Brumley, MO | 103 | 82 | 17.6% |
| Tuscumbia, MO | 167 | 84 | 15.9% |
| City | Population | Cost of Living Index | National Avg. |
| Tomales, CA | 167 | 179 | 79.5% |
| Rock Falls, IA | 167 | 89 | 10.8% |
| Westphalia, IA | 167 | 84 | 16.0% |
| Ferris, IL | 167 | 80 | 19.6% |
| Colburn, IN | 167 | 86 | 14.4% |
| Tuscumbia, MO | 167 | 84 | 15.9% |