| Index | South San Francisco | California | National |
| Income per capita | $70,343 | $45,980 | $44,883 |
| Median household income | $160,009 | $95,535 | $81,333 |
| Median income owner occupied | $192,713 | $130,228 | $106,172 |
| Median income renter occupied | $133,901 | $64,137 | $52,080 |
| Median earnings male | $74,631 | $52,776 | $54,343 |
| Median earnings female | $63,691 | $38,938 | $38,439 |
| Unemployment rate | 1.8% | 6.8% | 4.9% |
| Poverty level | 6.8% | 15.8% | 15.1% |

| Labour Type | Male | Female |
| Construction industry | 10.9% | 10.9% |
| Manufacturing sector | 7.5% | 7.5% |
| Financial & insurance services | 3.9% | 3.9% |
| Wholesale & retail services | 15.0% | 15.0% |
| Public administration | 4.1% | 4.1% |
| Transportation, warehousing & utilities | 10.4% | 10.4% |
| Education, health & social services | 12.9% | 12.9% |
| Other | 32.5% | 32.5% |
| City | Population | Household Income | National Avg. |
| Atherton, CA | 7,303 | $377,485 | 364.1% |
| Hillsborough, CA | 11,923 | $376,687 | 363.1% |
| Emerald Lake Hills, CA | 5,043 | $370,188 | 355.2% |
| Piedmont, CA | 11,734 | $367,407 | 351.7% |
| El Granada, CA | 6,263 | $290,151 | 256.7% |
| South San Francisco, CA | 68,998 | $160,009 | 96.7% |
| City | Population | Household Income | National Avg. |
| Alpharetta, GA | 69,031 | $176,078 | 116.5% |
| Portland, ME | 68,956 | $91,459 | 12.5% |
| Mount Vernon, NY | 69,130 | $88,733 | 9.1% |
| Johnson City, TN | 69,135 | $61,646 | 24.2% |
| Rocklin, CA | 69,145 | $150,823 | 85.4% |
| South San Francisco, CA | 68,998 | $160,009 | 96.7% |