An overview of the general cost of living index for Sanibel, FL is displayed above for your reference. Residents in Sanibel, FL enjoy a cost of living index of 168. This index is 69% higher than the Florida average, and 68% higher than the national average. The following categories are used when determining the cost of living index for any given city: health care (5%), transportation (9%), utilities (10%), groceries (13%), housing (30%), and goods/services (33%). Clearly, housing and goods/services make up the majority of the formula for calculating the cost of living index. Because of this, the general cost of living for any given area can be estimated by looking at the cost of everyday goods in that area. For those living in Sanibel, FL, the average cost of goods and services is 10% higher than it is in Florida, and it is 9% higher than the national average.