Prentiss, MS has a population of 1,370 and is the 13,222nd largest city in the United States. The population density is 458 per sq mi which is 643% higher than the Mississippi average and 406% higher than the national average. The median age in Prentiss is 42 which is approximately 14% higher than the Mississippi average of 37. In Prentiss, 50% of the population over 15 years of age are married, 100% speak English and 0% speak Spanish. 82% of Prentiss residents were born in Mississippi, 18% were born out of state, 0% were born outside of the United States and 0% were foreign born.