Osyka, MS has a population of 420 and is the 20,601st largest city in the United States. The population density is 397 per sq mi which is 544% higher than the Mississippi average and 338% higher than the national average. The median age in Osyka is 29 which is approximately 22% lower than the Mississippi average of 37. In Osyka, 50% of the population over 15 years of age are married, 97% speak English and 1% speak Spanish. 58% of Osyka residents were born in Mississippi, 38% were born out of state, 2% were born outside of the United States and 2% were foreign born.