New Melle, MO has a population of 496 and is the 19,586th largest city in the United States. The population density is 285 per sq mi which is 229% higher than the Missouri average and 214% higher than the national average. The median age in New Melle is 54 which is approximately 42% higher than the Missouri average of 38. In New Melle, 77% of the population over 15 years of age are married, 95% speak English and 1% speak Spanish. 73% of New Melle residents were born in Missouri, 25% were born out of state, 0% were born outside of the United States and 2% were foreign born.