Murphysboro, IL has a population of 8,007 and is the 4,674th largest city in the United States. The population density is 1,545 per sq mi which is 595% higher than the Illinois average and 1605% higher than the national average. The median age in Murphysboro is 38 which is approximately 1% higher than the Illinois average of 37. In Murphysboro, 52% of the population over 15 years of age are married, 97% speak English and 2% speak Spanish. 75% of Murphysboro residents were born in Illinois, 23% were born out of state, 0% were born outside of the United States and 1% were foreign born.