| Index | Murphysboro | Illinois | National |
| Cost of living | 82 | 98 | 100 |
| Groceries | 97 | 100 | 100 |
| Health care | 96 | 100 | 100 |
| Housing | 46 | 95 | 100 |
| Transportation | 99 | 101 | 100 |
| Utilities | 98 | 99 | 100 |
| Lifestyle & Entertainment | 95 | 100 | 100 |
| Household Items | 99 | 100 | 100 |
| Education & Childcare | 96 | 100 | 100 |

| Cost of living index | |
| Groceries index | |
| Health care index | |
| Housing index | |
| Transportation index | |
| Utilities index | |
| Lifestyle index | |
| Household index | |
| Educare index |
| Median Income | Per Year | Per Month | Max Budget (28% DTI) | Max Budget (36% DTI) |
| Owners | $75,312 | $6,276 | $1,757 | $2,260 |
| Renters | $37,701 | $3,142 | $880 | $1,131 |
| State | General Sales Tax | With Max Surtax |
| Illinois | 6.25% | 10.25% |
| State | Income Tax (Low) | Income Tax (High) |
| Illinois | 4.95% | 4.95% |
| City | Population | Cost of Living Index | National Avg. |
| Mulkeytown, IL | 132 | 97 | 3.0% |
| Gorham, IL | 273 | 76 | 24.5% |
| Grand Tower, IL | 610 | 77 | 22.8% |
| Hurst, IL | 781 | 78 | 21.7% |
| Dowell, IL | 364 | 78 | 21.6% |
| Murphysboro, IL | 7,983 | 82 | 18.2% |
| City | Population | Cost of Living Index | National Avg. |
| Union, SC | 7,981 | 84 | 15.5% |
| Joshua Tree, CA | 7,980 | 107 | 6.8% |
| Odessa, FL | 7,980 | 123 | 22.6% |
| Pomona, NJ | 7,980 | 107 | 7.5% |
| Beckwith, ON | 7,986 | n/a | |
| Murphysboro, IL | 7,983 | 82 | 18.2% |