Manistee, MI has a population of 6,100 and is the 5,701st largest city in the United States. The population density is 1,860 per sq mi which is 1745% higher than the Michigan average and 1953% higher than the national average. The median age in Manistee is 44 which is approximately 11% higher than the Michigan average of 40. In Manistee, 51% of the population over 15 years of age are married, 97% speak English and 1% speak Spanish. 79% of Manistee residents were born in Michigan, 20% were born out of state, 0% were born outside of the United States and 1% were foreign born.