La Mesa, CA has a population of 59,125 and is the 665th largest city in the United States. The population density is 6,502 per sq mi which is 2698% higher than the California average and 7076% higher than the national average. The median age in La Mesa is 37 which is approximately 2% higher than the California average of 36. In La Mesa, 51% of the population over 15 years of age are married, 76% speak English and 14% speak Spanish. 55% of La Mesa residents were born in California, 28% were born out of state, 2% were born outside of the United States and 15% were foreign born.