Florence, MS has a population of 4,313 and is the 7,100th largest city in the United States. The population density is 531 per sq mi which is 761% higher than the Mississippi average and 486% higher than the national average. The median age in Florence is 32 which is approximately 12% lower than the Mississippi average of 37. In Florence, 59% of the population over 15 years of age are married, 99% speak English and 1% speak Spanish. 82% of Florence residents were born in Mississippi, 16% were born out of state, 1% were born outside of the United States and 0% were foreign born.