| Index | East Prairie | Missouri | National |
| Income per capita | $28,282 | $39,715 | $44,883 |
| Median household income | $41,440 | $72,613 | $81,333 |
| Median income owner occupied | $56,194 | $90,986 | $106,172 |
| Median income renter occupied | $31,157 | $45,210 | $52,080 |
| Median earnings male | $53,052 | $52,324 | $54,343 |
| Median earnings female | $31,498 | $36,971 | $38,439 |
| Unemployment rate | 4.6% | 4.4% | 4.9% |
| Poverty level | 24.0% | 15.3% | 15.1% |

| Labour Type | Male | Female |
| Construction industry | 0.0% | 0.0% |
| Manufacturing sector | 17.3% | 17.3% |
| Financial & insurance services | 0.0% | 0.0% |
| Wholesale & retail services | 12.3% | 12.3% |
| Public administration | 2.4% | 2.4% |
| Transportation, warehousing & utilities | 21.2% | 21.2% |
| Education, health & social services | 14.9% | 14.9% |
| Other | 31.9% | 31.9% |
| City | Population | Household Income | National Avg. |
| Miner, MO | 901 | $66,685 | 18.0% |
| North Lilbourn, MO | 191 | $64,020 | 21.3% |
| Sikeston, MO | 17,170 | $63,160 | 22.3% |
| New Madrid, MO | 2,946 | $62,917 | 22.6% |
| Bertrand, MO | 803 | $56,352 | 30.7% |
| East Prairie, MO | 3,072 | $41,440 | 49.0% |
| City | Population | Household Income | National Avg. |
| Hennessey, OK | 3,072 | $75,542 | 7.1% |
| Stanton, TX | 3,072 | $89,279 | 9.8% |
| Minburn County No. 27, AB | 3,072 | n/a | |
| Two Hills County No. 21, AB | 3,071 | n/a | |
| East Douglas, MA | 3,073 | $114,296 | 40.5% |
| East Prairie, MO | 3,072 | $41,440 | 49.0% |