| Index | Sikeston | Missouri | National |
| Income per capita | $40,265 | $39,715 | $44,883 |
| Median household income | $63,160 | $72,613 | $81,333 |
| Median income owner occupied | $81,145 | $90,986 | $106,172 |
| Median income renter occupied | $41,281 | $45,210 | $52,080 |
| Median earnings male | $52,820 | $52,324 | $54,343 |
| Median earnings female | $37,994 | $36,971 | $38,439 |
| Unemployment rate | 2.1% | 4.4% | 4.9% |
| Poverty level | 20.0% | 15.3% | 15.1% |

| Labour Type | Male | Female |
| Construction industry | 3.2% | 3.2% |
| Manufacturing sector | 23.2% | 23.2% |
| Financial & insurance services | 1.5% | 1.5% |
| Wholesale & retail services | 13.8% | 13.8% |
| Public administration | 8.5% | 8.5% |
| Transportation, warehousing & utilities | 6.0% | 6.0% |
| Education, health & social services | 11.5% | 11.5% |
| Other | 29.5% | 29.5% |
| City | Population | Household Income | National Avg. |
| Benton, MO | 904 | $96,947 | 19.2% |
| Blodgett, MO | 148 | $86,600 | 6.5% |
| Grayridge, MO | 150 | $71,395 | 12.2% |
| Vanduser, MO | 188 | $70,947 | 12.8% |
| Miner, MO | 901 | $66,685 | 18.0% |
| Sikeston, MO | 17,170 | $63,160 | 22.3% |
| City | Population | Household Income | National Avg. |
| Cohoes, NY | 17,198 | $81,562 | 0.3% |
| Republic, MO | 17,135 | $82,772 | 1.8% |
| Clayton, MO | 17,205 | $164,109 | 101.8% |
| New Port Richey, FL | 17,130 | $55,218 | 32.1% |
| Highland Village, TX | 17,130 | $217,948 | 168.0% |
| Sikeston, MO | 17,170 | $63,160 | 22.3% |