| Index | De Soto | Wisconsin | National |
| Income per capita | $43,231 | $43,754 | $44,883 |
| Median household income | $116,598 | $81,774 | $81,333 |
| Median income owner occupied | $132,744 | $103,160 | $106,172 |
| Median income renter occupied | $40,601 | $47,125 | $52,080 |
| Median earnings male | $67,432 | $54,326 | $54,343 |
| Median earnings female | $51,784 | $38,113 | $38,439 |
| Unemployment rate | 0.5% | 3.9% | 4.9% |
| Poverty level | 6.8% | 12.7% | 15.1% |

| Labour Type | Male | Female |
| Construction industry | 6.5% | 6.5% |
| Manufacturing sector | 17.7% | 17.7% |
| Financial & insurance services | 0.0% | 0.0% |
| Wholesale & retail services | 4.8% | 4.8% |
| Public administration | 4.0% | 4.0% |
| Transportation, warehousing & utilities | 2.4% | 2.4% |
| Education, health & social services | 54.0% | 54.0% |
| Other | 7.3% | 7.3% |
| City | Population | Household Income | National Avg. |
| Genoa, WI | 247 | $81,782 | 0.6% |
| Lynxville, WI | 115 | $81,327 | 0.0% |
| Caledonia, MN | 2,816 | $75,979 | 6.6% |
| Waukon, IA | 3,770 | $72,568 | 10.8% |
| New Albin, IA | 522 | $69,494 | 14.6% |
| De Soto, WI | 525 | $116,598 | 43.4% |
| City | Population | Household Income | National Avg. |
| La Paz Valley, AZ | 525 | $45,245 | 44.4% |
| Buckley, IL | 525 | $85,456 | 5.1% |
| Reynolds, IN | 525 | $82,158 | 1.0% |
| Grosse Tete, LA | 525 | $68,646 | 15.6% |
| South Range, MI | 525 | $45,194 | 44.4% |
| De Soto, WI | 525 | $116,598 | 43.4% |