De Soto, WI has a population of 301 and is the 22,486th largest city in the United States. The population density is 247 per sq mi which is 182% higher than the Wisconsin average and 172% higher than the national average. The median age in De Soto is 48 which is approximately 22% higher than the Wisconsin average of 39. In De Soto, 52% of the population over 15 years of age are married, 99% speak English and 1% speak Spanish. 83% of De Soto residents were born in Wisconsin, 16% were born out of state, 0% were born outside of the United States and 1% were foreign born.