Clarksdale, MO has a population of 258 and is the 23,274th largest city in the United States. The population density is 797 per sq mi which is 822% higher than the Missouri average and 779% higher than the national average. The median age in Clarksdale is 47 which is approximately 23% higher than the Missouri average of 38. In Clarksdale, 72% of the population over 15 years of age are married, 99% speak English and 1% speak Spanish. 80% of Clarksdale residents were born in Missouri, 19% were born out of state, 1% were born outside of the United States and 0% were foreign born.