| Index | Clarksdale | Missouri | National |
| Cost of living | 77 | 90 | 100 |
| Groceries | 95 | 96 | 100 |
| Health care | 97 | 97 | 100 |
| Housing | 33 | 77 | 100 |
| Transportation | 95 | 96 | 100 |
| Utilities | 97 | 95 | 100 |
| Lifestyle & Entertainment | 99 | 95 | 100 |
| Household Items | 97 | 97 | 100 |
| Education & Childcare | 93 | 95 | 100 |

| Cost of living index | |
| Groceries index | |
| Health care index | |
| Housing index | |
| Transportation index | |
| Utilities index | |
| Lifestyle index | |
| Household index | |
| Educare index |
| Median Income | Per Year | Per Month | Max Budget (28% DTI) | Max Budget (36% DTI) |
| Owners | $77,396 | $6,450 | $1,806 | $2,322 |
| Renters | $38,753 | $3,229 | $904 | $1,163 |
| State | General Sales Tax | With Max Surtax |
| Missouri | 4.225% | 10.85% |
| State | Income Tax (Low) | Income Tax (High) |
| Missouri | 2% | 4.95% |
| City | Population | Cost of Living Index | National Avg. |
| Amity, MO | 57 | 69 | 31.2% |
| Osborn, MO | 414 | 81 | 19.1% |
| Easton, MO | 313 | 82 | 18.4% |
| Union Star, MO | 576 | 82 | 18.4% |
| Cosby, MO | 206 | 83 | 16.8% |
| Clarksdale, MO | 269 | 77 | 23.0% |
| City | Population | Cost of Living Index | National Avg. |
| Industry, CA | 269 | 137 | 37.1% |
| Crystal Lake, IA | 269 | 83 | 16.7% |
| Lineville, IA | 269 | 77 | 23.1% |
| Magnolia, IL | 269 | 87 | 13.4% |
| Jeff, KY | 269 | 98 | 2.0% |
| Clarksdale, MO | 269 | 77 | 23.0% |