| Index | Chillicothe | Ohio | National |
| Income per capita | $29,467 | $27,800 | $29,829 |
| Median household income | $45,251 | $50,674 | $55,322 |
| Median income owner occupied | $67,039 | $65,077 | $70,586 |
| Median income renter occupied | $29,873 | $28,832 | $35,192 |
| Median earnings male | $40,044 | $36,579 | $36,919 |
| Median earnings female | $25,529 | $24,862 | $26,250 |
| Unemployment rate | 3.4% | 4.6% | 4.7% |
| Poverty level | 18.1% | 15.4% | 15.1% |


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| Labour Type | Male | Female |
| Construction industry | 7.6% | 7.6% |
| Manufacturing sector | 24.5% | 24.5% |
| Financial & insurance services | 2.5% | 2.5% |
| Wholesale & retail services | 16.0% | 16.0% |
| Public administration | 6.6% | 6.6% |
| Transportation, warehousing & utilities | 6.5% | 6.5% |
| Education, health & social services | 16.3% | 16.3% |
| Other | 19.2% | 19.2% |
| City | Population | Household Income | National Avg. |
| Andersonville, OH | 584 | $96,250 | 74.0% |
| Tarlton, OH | 294 | $66,875 | 20.9% |
| Frankfort, OH | 1,314 | $45,813 | 17.2% |
| Waverly, OH | 4,186 | $45,509 | 17.7% |
| Adelphi, OH | 371 | $45,313 | 18.1% |
| Chillicothe, OH | 21,668 | $45,251 | 18.2% |
| City | Population | Household Income | National Avg. |
| Alliance, OH | 21,671 | $36,883 | 33.3% |
| Raymore, MO | 21,676 | $86,368 | 56.1% |
| Gallup, NM | 21,637 | $45,754 | 17.3% |
| Roselle, NJ | 21,699 | $65,307 | 18.0% |
| Yucca Valley, CA | 21,701 | $47,901 | 13.4% |
| Chillicothe, OH | 21,668 | $45,251 | 18.2% |