I live in North Carolina, not so far from Winston Salem. My wife and I always enjoy visiting the city . For us, the number 1 attraction in Winston Salem and the place we enjoy most is Old Salem. This authentic European-style village was restored to show what life was like in the early days of our country. It will probably exceed your expectations; but don't go on Sundays, because some buildings are not open.
The SciWorks and Children's Museum of Salem both have interesting exhibits and are well worth a visit. The Children's Museum has many interactive displays and proved to be a fun stop for kids.
Winston Salem is the home base where Krispy Kreme donuts were first created. If you are so unfortunate as to not have eaten them (and even if you have), you must pay this scrumptious place a visit.
This city is also the home of Wake Forest University. It is one of the great universities in the south. Overall, there are many reason to visit the city of Winston Salem, even though I have only named a few.