Wapello, IA has a population of 1,922 and is the 11,246th largest city in the United States. The population density is 1,485 per sq mi which is 2618% higher than the Iowa average and 1539% higher than the national average. The median age in Wapello is 39 which is approximately 2% higher than the Iowa average of 38. In Wapello, 61% of the population over 15 years of age are married, 91% speak English and 9% speak Spanish. 75% of Wapello residents were born in Iowa, 19% were born out of state, 0% were born outside of the United States and 6% were foreign born.