Is St. Louis safe? Listed below are the safest neighborhoods in St. Louis for 2022. Rankings are based on total crimes per 100,000 people for each neighborhood when compared to the St. Louis average. Total crimes include both violent crimes (murder, rape, robbery, assault) and property crimes (burglary, theft, vehicle theft). Total crimes include crime data provided by local law enforcement agencies and if not available, could also include estimates based on various demographic data.