| Index | Santee | Nebraska | National |
| Average Test Scores | n/a | 53% | 48% |
| Student/Teacher ratio | n/a | 13:1 | 16:1 |
| Total public schools | n/a | 780 | 79,221 |
| Total private schools | n/a | 182 | 24,874 |
| Total post-secondary schools | n/a | 56 | 7,963 |

| Index | Santee | Nebraska | National |
| Completed 8th grade | 71.7% | 88.4% | 84.3% |
| Completed high school | 70.5% | 87.2% | 83.0% |
| Completed some college | 51.8% | 63.7% | 59.4% |
| Completed associate degree | 18.1% | 40.1% | 38.5% |
| Completed bachelors | 7.2% | 30.0% | 30.3% |
| Completed masters | 4.8% | 9.9% | 11.5% |
| Completed professional degree | 1.2% | 2.9% | 3.3% |
| Completed doctorate | 1.2% | 1.2% | 1.3% |
There are a total of n/a public schools, n/a private schools and n/a post-secondary schools in Santee. Using the proficiency score averages, the average test scores for Santee, NE schools is n/a. The average student to teacher ratio is n/a. In Santee, NE, an average of 71.7% of students have completed 8th grade and an average of 70.5% have completed high school.
| City | Population | Avg. Test Scores | National Avg. |
| Springfield, SD | 2,175 | 70% | 45.8% |
| Avon, SD | 824 | 56% | 16.0% |
| Tyndall, SD | 1,191 | 52% | 7.3% |
| Tabor, SD | 444 | 45% | 6.3% |
| Niobrara, NE | 333 | 22% | 54.7% |
| Santee, NE | 371 | n/a |
| City | Population | Avg. Test Scores | National Avg. |
| Arcadia, NE | 371 | 53% | 9.4% |
| Wilson, TX | 371 | 32% | 33.3% |
| Protection, KS | 370 | 39% | 19.8% |
| Shonto, AZ | 370 | 31% | 34.9% |
| Willisburg, KY | 370 | 61% | 26.0% |
| Santee, NE | 371 | n/a |