Pilot Knob, MO has a population of 738 and is the 17,137th largest city in the United States. The population density is 823 per sq mi which is 853% higher than the Missouri average and 809% higher than the national average. The median age in Pilot Knob is 41 which is approximately 6% higher than the Missouri average of 38. In Pilot Knob, 60% of the population over 15 years of age are married, 100% speak English and 0% speak Spanish. 82% of Pilot Knob residents were born in Missouri, 17% were born out of state, 1% were born outside of the United States and 0% were foreign born.