| Index | Murphysboro | Illinois | National |
| Average Test Scores | 19% | 33% | 48% |
| Student/Teacher ratio | 17:1 | 18:1 | 16:1 |
| Total public schools | 9 | 3,938 | 79,221 |
| Total private schools | 4 | 1,438 | 24,874 |
| Total post-secondary schools | n/a | 306 | 7,963 |


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| Index | Murphysboro | Illinois | National |
| Completed 8th grade | 80.3% | 86.2% | 84.3% |
| Completed high school | 76.6% | 84.7% | 83.0% |
| Completed some college | 47.2% | 61.8% | 59.4% |
| Completed associate degree | 28.4% | 40.7% | 38.5% |
| Completed bachelors | 20.1% | 32.9% | 30.3% |
| Completed masters | 8.5% | 12.7% | 11.5% |
| Completed professional degree | 3.0% | 3.4% | 3.3% |
| Completed doctorate | 1.2% | 1.2% | 1.3% |
There are a total of 9 public schools, 4 private schools and n/a post-secondary schools in Murphysboro. Using the proficiency score averages, the average test scores for Murphysboro, IL schools is 19%. The average student to teacher ratio is 17:1. In Murphysboro, IL, an average of 80.3% of students have completed 8th grade and an average of 76.6% have completed high school.
| City | Population | Avg. Test Scores | National Avg. |
| Carterville, IL | 5,861 | 53% | 10.9% |
| Altenburg, MO | 345 | 45% | 6.3% |
| Vergennes, IL | 238 | 37% | 22.9% |
| Carbondale, IL | 25,400 | 34% | 29.3% |
| Elkville, IL | 796 | 30% | 37.5% |
| Murphysboro, IL | 7,727 | 19% | 59.7% |
| City | Population | Avg. Test Scores | National Avg. |
| Holly Springs, MS | 7,727 | 25% | 47.5% |
| Pittston, PA | 7,729 | 56% | 17.0% |
| South Beloit, IL | 7,730 | 36% | 25.3% |
| Baldwinsville, NY | 7,732 | 53% | 10.0% |
| Providence, UT | 7,732 | 59% | 21.9% |
| Murphysboro, IL | 7,727 | 19% | 59.7% |