Missouri City, MO has a population of 449 and is the 20,217th largest city in the United States. The population density is 503 per sq mi which is 482% higher than the Missouri average and 455% higher than the national average. The median age in Missouri City is 50 which is approximately 30% higher than the Missouri average of 38. In Missouri City, 61% of the population over 15 years of age are married, 99% speak English and 0% speak Spanish. 72% of Missouri City residents were born in Missouri, 27% were born out of state, 0% were born outside of the United States and 1% were foreign born.