| Index | Matlacha Isles-Matlacha Shores | Florida | National |
| Income per capita | $34,351 | $40,554 | $44,883 |
| Median household income | $111,171 | $72,078 | $81,333 |
| Median income owner occupied | $136,891 | $88,075 | $106,172 |
| Median income renter occupied | $0 | $51,794 | $52,080 |
| Median earnings male | $0 | $45,688 | $54,343 |
| Median earnings female | $0 | $37,493 | $38,439 |
| Unemployment rate | 0.0% | 5.2% | 4.9% |
| Poverty level | 0.0% | 16.1% | 15.1% |

| Labour Type | Male | Female |
| Construction industry | 74.2% | 74.2% |
| Manufacturing sector | 0.0% | 0.0% |
| Financial & insurance services | 0.0% | 0.0% |
| Wholesale & retail services | 25.8% | 25.8% |
| Public administration | 0.0% | 0.0% |
| Transportation, warehousing & utilities | 0.0% | 0.0% |
| Education, health & social services | 0.0% | 0.0% |
| Other | 0.0% | 0.0% |
| City | Population | Household Income | National Avg. |
| Sanibel, FL | 7,660 | $137,514 | 69.1% |
| Burnt Store Marina, FL | 2,216 | $135,238 | 66.3% |
| Whiskey Creek, FL | 5,657 | $114,737 | 41.1% |
| Fort Myers Beach, FL | 7,313 | $113,689 | 39.8% |
| Lochmoor Waterway Estates, FL | 5,159 | $111,192 | 36.7% |
| Matlacha Isles-Matlacha Shores, FL | 352 | $111,171 | 36.7% |
| City | Population | Household Income | National Avg. |
| Mitchellville, AR | 352 | $29,840 | 63.3% |
| Odum, GA | 352 | $69,203 | 14.9% |
| Universal, IN | 352 | $71,480 | 12.1% |
| Jasper, MI | 352 | $90,959 | 11.8% |
| Rushmore, MN | 352 | $61,066 | 24.9% |
| Matlacha Isles-Matlacha Shores, FL | 352 | $111,171 | 36.7% |