| Index | Matlacha Isles-Matlacha Shores | Florida | National |
| Income per capita | $22,627 | $27,598 | $29,829 |
| Median household income | $73,836 | $48,900 | $55,322 |
| Median income owner occupied | $91,190 | $59,209 | $70,586 |
| Median income renter occupied | $0 | $34,622 | $35,192 |
| Median earnings male | $0 | $31,444 | $36,919 |
| Median earnings female | $0 | $25,332 | $26,250 |
| Unemployment rate | 0.0% | 4.9% | 4.7% |
| Poverty level | 0.0% | 16.1% | 15.1% |


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| Labour Type | Male | Female |
| Construction industry | 74.2% | 74.2% |
| Manufacturing sector | 0.0% | 0.0% |
| Financial & insurance services | 0.0% | 0.0% |
| Wholesale & retail services | 25.8% | 25.8% |
| Public administration | 0.0% | 0.0% |
| Transportation, warehousing & utilities | 0.0% | 0.0% |
| Education, health & social services | 0.0% | 0.0% |
| Other | 0.0% | 0.0% |
| City | Population | Household Income | National Avg. |
| Sanibel, FL | 7,378 | $92,875 | 67.9% |
| Burnt Store Marina, FL | 2,140 | $89,417 | 61.6% |
| Whiskey Creek, FL | 5,508 | $76,455 | 38.2% |
| Fort Myers Beach, FL | 7,102 | $75,919 | 37.2% |
| Punta Rassa, FL | 1,566 | $75,580 | 36.6% |
| Matlacha Isles-Matlacha Shores, FL | 339 | $73,836 | 33.5% |
| City | Population | Household Income | National Avg. |
| Mitchellville, AR | 339 | $19,688 | 64.4% |
| Vineland, CO | 339 | $61,875 | 11.8% |
| McIntosh, FL | 339 | $52,174 | 5.7% |
| Keysville, GA | 339 | $47,500 | 14.1% |
| Lacona, IA | 339 | $57,750 | 4.4% |
| Matlacha Isles-Matlacha Shores, FL | 339 | $73,836 | 33.5% |