| Index | Matlacha Isles-Matlacha Shores | Florida | National |
| Cost of living | 127 | 98 | 100 |
| Goods & Services | 105 | 98 | 100 |
| Groceries | 99 | 99 | 100 |
| Health care | 108 | 96 | 100 |
| Housing | 183 | 96 | 100 |
| Transportation | 107 | 99 | 100 |
| Utilities | 96 | 97 | 100 |


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| Cost of living index | |
| Goods & Services index | |
| Groceries index | |
| Health care index | |
| Housing index | |
| Transportation index | |
| Utilities index |
| Median Income | Per Year | Per Month | Max Budget (28% DTI) | Max Budget (36% DTI) |
| Owners | $91,190 | $7,599 | $2,128 | $2,736 |
| Renters | $0 | $0 | $0 | $0 |
| State | General Sales Tax | With Max Surtax |
| Florida | 6% | 7.5% |
| State | Income Tax (Low) | Income Tax (High) |
| Florida | 0% | 0% |
| Item | Matlacha Isles-Matlacha Shores | National avg. | Difference |
| Haircut | $28.20 | $24.26 | 16.2% |
| Beauty Salon | $54.05 | $45.56 | 18.6% |
| Toothpaste | $3.63 | $3.70 | 1.9% |
| Shampoo | $1.45 | $1.28 | 13.5% |
| Movie | $13.05 | $12.13 | 7.6% |
| Bowling | $21.20 | $18.00 | 17.8% |
| Item | Matlacha Isles-Matlacha Shores | National avg. | Difference |
| Ground Beef | $6.06 | $5.84 | 3.8% |
| Fried Chicken | $1.40 | $1.57 | 11.0% |
| Milk | $4.57 | $4.67 | 2.2% |
| Potatoes | $5.24 | $4.93 | 6.1% |
| Pizza | $11.72 | $12.09 | 3.0% |
| Beer | $11.06 | $10.41 | 6.2% |
| Item | Matlacha Isles-Matlacha Shores | National avg. | Difference |
| Optometrist | $101.67 | $125.68 | 19.1% |
| Doctor | $153.94 | $135.78 | 13.4% |
| Dentist | $122.09 | $113.29 | 7.8% |
| Ibuprofen | $10.59 | $10.65 | 0.6% |
| Lipitor | $535.04 | $468.60 | 14.2% |
| Item | Matlacha Isles-Matlacha Shores | National avg. | Difference |
| Home Price | $338,700.00 | $184,700.00 | 83.4% |
| Avg. Mortgage Payment | $2,422.46 | $2,346.69 | 3.2% |
| Apartment Rent | $0.00 | $949.00 | 100.0% |
| Item | Matlacha Isles-Matlacha Shores | National avg. | Difference |
| Gasoline | $3.47 | $3.46 | 0.2% |
| Tire Balancing | $74.92 | $59.92 | 25.0% |
| Item | Matlacha Isles-Matlacha Shores | National avg. | Difference |
| All Electricity | $179.36 | $193.99 | 7.5% |
| Phone | $194.07 | $192.25 | 0.9% |
| City | Population | Cost of Living Index | National Avg. |
| Suncoast Estates, FL | 4,759 | 88 | 11.6% |
| North Fort Myers, FL | 42,315 | 92 | 8.1% |
| Tice, FL | 5,379 | 93 | 6.7% |
| Pine Manor, FL | 4,582 | 95 | 5.1% |
| Harlem Heights, FL | 1,362 | 95 | 4.7% |
| Matlacha Isles-Matlacha Shores, FL | 339 | 127 | 27.0% |
| City | Population | Cost of Living Index | National Avg. |
| Mitchellville, AR | 339 | 79 | 20.8% |
| Vineland, CO | 339 | 99 | 1.4% |
| McIntosh, FL | 339 | 90 | 9.6% |
| Keysville, GA | 339 | 83 | 16.8% |
| Lacona, IA | 339 | 81 | 18.6% |
| Matlacha Isles-Matlacha Shores, FL | 339 | 127 | 27.0% |