Lupus, MO has a population of 30 and is the 28,598th largest city in the United States. The population density is 162 per sq mi which is 88% higher than the Missouri average and 79% higher than the national average. The median age in Lupus is 61 which is approximately 59% higher than the Missouri average of 38. In Lupus, 33% of the population over 15 years of age are married, 100% speak English and 0% speak Spanish. 70% of Lupus residents were born in Missouri, 30% were born out of state, 0% were born outside of the United States and 0% were foreign born.