Greenville, MO has a population of 563 and is the 18,817th largest city in the United States. The population density is 834 per sq mi which is 866% higher than the Missouri average and 821% higher than the national average. The median age in Greenville is 32 which is approximately 15% lower than the Missouri average of 38. In Greenville, 63% of the population over 15 years of age are married, 99% speak English and 1% speak Spanish. 87% of Greenville residents were born in Missouri, 12% were born out of state, 0% were born outside of the United States and 1% were foreign born.