| Index | De Soto | Missouri | National |
| Income per capita | $32,768 | $39,715 | $44,883 |
| Median household income | $59,001 | $72,613 | $81,333 |
| Median income owner occupied | $75,826 | $90,986 | $106,172 |
| Median income renter occupied | $33,533 | $45,210 | $52,080 |
| Median earnings male | $65,557 | $52,324 | $54,343 |
| Median earnings female | $23,749 | $36,971 | $38,439 |
| Unemployment rate | 6.3% | 4.4% | 4.9% |
| Poverty level | 16.3% | 15.3% | 15.1% |

| Labour Type | Male | Female |
| Construction industry | 22.2% | 22.2% |
| Manufacturing sector | 12.2% | 12.2% |
| Financial & insurance services | 0.0% | 0.0% |
| Wholesale & retail services | 24.7% | 24.7% |
| Public administration | 5.1% | 5.1% |
| Transportation, warehousing & utilities | 9.7% | 9.7% |
| Education, health & social services | 7.6% | 7.6% |
| Other | 17.6% | 17.6% |
| City | Population | Household Income | National Avg. |
| Barnhart, MO | 6,838 | $126,516 | 55.6% |
| Valmeyer, IL | 1,236 | $120,746 | 48.5% |
| Cedar Hill, MO | 1,686 | $103,186 | 26.9% |
| Imperial, MO | 5,109 | $100,789 | 23.9% |
| Herculaneum, MO | 4,222 | $99,649 | 22.5% |
| De Soto, MO | 6,612 | $59,001 | 27.5% |
| City | Population | Household Income | National Avg. |
| West Yarmouth, MA | 6,612 | $84,935 | 4.4% |
| Galax, VA | 6,612 | $53,283 | 34.5% |
| Rittman, OH | 6,610 | $71,741 | 11.8% |
| Bowleys Quarters, MD | 6,614 | $143,958 | 77.0% |
| Howland Center, OH | 6,609 | $108,481 | 33.4% |
| De Soto, MO | 6,612 | $59,001 | 27.5% |