De Kalb, MO has a population of 192 and is the 24,642nd largest city in the United States. The population density is 753 per sq mi which is 771% higher than the Missouri average and 731% higher than the national average. The median age in De Kalb is 42 which is approximately 8% higher than the Missouri average of 38. In De Kalb, 67% of the population over 15 years of age are married, 100% speak English and 0% speak Spanish. 68% of De Kalb residents were born in Missouri, 32% were born out of state, 0% were born outside of the United States and 0% were foreign born.