Seguin, TX has a population of 27,543 and is the 1,561st largest city in the United States. The population density is 742 per sq mi which is 665% higher than the Texas average and 719% higher than the national average. The median age in Seguin is 36 which is approximately 6% higher than the Texas average of 34. In Seguin, 51% of the population over 15 years of age are married, 66% speak English and 32% speak Spanish. 77% of Seguin residents were born in Texas, 14% were born out of state, 1% were born outside of the United States and 7% were foreign born.