Santa Clara, TX has a population of 807 and is the 16,552nd largest city in the United States. The population density is 375 per sq mi which is 286% higher than the Texas average and 313% higher than the national average. The median age in Santa Clara is 43 which is approximately 25% higher than the Texas average of 34. In Santa Clara, 72% of the population over 15 years of age are married, 85% speak English and 12% speak Spanish. 72% of Santa Clara residents were born in Texas, 24% were born out of state, 2% were born outside of the United States and 1% were foreign born.