| Statistic | Santa Ana Pueblo | New Mexico | National |
| Population | 944 | 2,096,829 | 328,239,523 |
| Population density (sq mi) | 128 | 17 | 91 |
| Median age | 35.2 | 37.2 | 37.7 |
| Male/Female ratio | 1.4:1 | 1.0:1 | 1.0:1 |
| Married (15yrs & older) | 30% | 52% | 55% |
| Families w/ Kids under 18 | 18% | 42% | 43% |
| Speak English | 33% | 65% | 79% |
| Speak Spanish | 1% | 28% | 13% |
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| Race | Santa Ana Pueblo | New Mexico | National |
| White | 1.27% | 73.49% | 73.35% |
| Black | 0.00% | 2.01% | 12.63% |
| Asian | 0.00% | 1.40% | 5.22% |
| American Indian | 94.92% | 9.28% | 0.82% |
| Native Hawaiian | 0.64% | 0.06% | 0.18% |
| Mixed race | 2.65% | 3.26% | 3.06% |
| Other race | 0.53% | 10.49% | 4.75% |
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