Panola, IL has a population of 49 and is the 28,179th largest city in the United States. The population density is 114 per sq mi which is 49% lower than the Illinois average and 26% higher than the national average. The median age in Panola is 38 which is approximately 2% higher than the Illinois average of 37. In Panola, 89% of the population over 15 years of age are married, 100% speak English and 0% speak Spanish. 82% of Panola residents were born in Illinois, 18% were born out of state, 0% were born outside of the United States and 0% were foreign born.