| Index | Panacea | Florida | National |
| Cost of living | 88 | 102 | 100 |
| Groceries | 103 | 102 | 100 |
| Health care | 105 | 104 | 100 |
| Housing | 48 | 97 | 100 |
| Transportation | 100 | 103 | 100 |
| Utilities | 115 | 110 | 100 |
| Lifestyle & Entertainment | 108 | 104 | 100 |
| Household Items | 101 | 102 | 100 |
| Education & Childcare | 111 | 106 | 100 |

| Cost of living index | |
| Groceries index | |
| Health care index | |
| Housing index | |
| Transportation index | |
| Utilities index | |
| Lifestyle index | |
| Household index | |
| Educare index |
| Median Income | Per Year | Per Month | Max Budget (28% DTI) | Max Budget (36% DTI) |
| Owners | $40,809 | $3,401 | $952 | $1,224 |
| Renters | $0 | $0 | $0 | $0 |
| State | General Sales Tax | With Max Surtax |
| Florida | 6% | 7.5% |
| State | Income Tax (Low) | Income Tax (High) |
| Florida | 0% | 0% |
| City | Population | Cost of Living Index | National Avg. |
| Sopchoppy, FL | 500 | 97 | 3.1% |
| Crawfordville, FL | 4,213 | 103 | 3.1% |
| St. Marks, FL | 349 | 118 | 17.9% |
| Panacea, FL | 765 | 88 | 11.8% |
| City | Population | Cost of Living Index | National Avg. |
| Plumerville, AR | 765 | 81 | 19.1% |
| Maxwell, IA | 765 | 85 | 14.9% |
| Gray, ME | 765 | 107 | 6.9% |
| Viburnum, MO | 765 | 82 | 18.5% |
| Pettit, OK | 765 | 87 | 12.5% |
| Panacea, FL | 765 | 88 | 11.8% |