Mayo, FL has a population of 1,104 and is the 14,531st largest city in the United States. The population density is 1,226 per sq mi which is 318% higher than the Florida average and 1253% higher than the national average. The median age in Mayo is 43 which is approximately 4% higher than the Florida average of 42. In Mayo, 43% of the population over 15 years of age are married, 81% speak English and 16% speak Spanish. 57% of Mayo residents were born in Florida, 27% were born out of state, 0% were born outside of the United States and 16% were foreign born.