| Index | Matlacha | Florida | National |
| Income per capita | $74,103 | $27,598 | $29,829 |
| Median household income | $60,513 | $48,900 | $55,322 |
| Median income owner occupied | $0 | $59,209 | $70,586 |
| Median income renter occupied | $38,487 | $34,622 | $35,192 |
| Median earnings male | $250,001 | $31,444 | $36,919 |
| Median earnings female | $16,075 | $25,332 | $26,250 |
| Unemployment rate | 3.6% | 4.9% | 4.7% |
| Poverty level | 10.6% | 16.1% | 15.1% |


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| Labour Type | Male | Female |
| Construction industry | 4.0% | 4.0% |
| Manufacturing sector | 4.5% | 4.5% |
| Financial & insurance services | 16.1% | 16.1% |
| Wholesale & retail services | 5.4% | 5.4% |
| Public administration | 0.0% | 0.0% |
| Transportation, warehousing & utilities | 0.0% | 0.0% |
| Education, health & social services | 8.5% | 8.5% |
| Other | 61.4% | 61.4% |
| City | Population | Household Income | National Avg. |
| Sanibel, FL | 7,378 | $92,875 | 67.9% |
| Burnt Store Marina, FL | 2,140 | $89,417 | 61.6% |
| Whiskey Creek, FL | 5,508 | $76,455 | 38.2% |
| Fort Myers Beach, FL | 7,102 | $75,919 | 37.2% |
| Punta Rassa, FL | 1,566 | $75,580 | 36.6% |
| Matlacha, FL | 853 | $60,513 | 9.4% |
| City | Population | Household Income | National Avg. |
| Oakman, AL | 853 | $20,893 | 62.2% |
| Quitman, AR | 853 | $36,667 | 33.7% |
| Lot 63, PE | 853 | n/a | |
| Saint-Henri-de-Taillon, QC | 853 | n/a | |
| Womens Bay, AK | 852 | $95,556 | 72.7% |
| Matlacha, FL | 853 | $60,513 | 9.4% |